The Buffalo Bills will look to move to 3-0 and keep the Jacksonville Jaguars winless when they meet in a key AFC matchup on Monday Night Football. Buffalo is coming off a 31-10 thrashing of the Miami Dolphins on Sept. 12, while Jacksonville dropped an 18-13 decision to the Cleveland Browns last Sunday. Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:30 p.m. ET.

Buffalo is a 5-point favorite and the over/under for total points scored is 45.5 in the latest Jaguars vs. Bills odds via SportsLine consensus. Before making any Jaguars vs. Bills picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of last season.

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Now, the model has set its sights on Jaguars vs. Bills. We can tell you the model is leaning Over the total, and it also says one side of the spread cashes in 60% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

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